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KMID : 0881720170320030243
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Journal of Food Hygiene and Safety
2017 Volume.32 No. 3 p.243 ~ p.248
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Antioxidant and Anti-aging Effects of Extracts from Leaves of Castanea crenata Siebold & Zucc. in Human Dermal Fibroblast
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Choi Sun-Il
Lee Jong-Seok
Lee Sa-Rah
Lee Hye-Jin
Kim Byung-Jik
Yeo Joo-Hong
Jung Tae-Dong
Cho Bong-Yeon
Choi Seung-Hyun
Lee Jin-Ha
Kim Jong-Yea
Lee Ok-Hwan
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Abstract
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Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) causes skin aging, which is characterized by wrinkles and atypical pigmentation. Use of antioxidant is an effective approach to prevent symptoms related to ROS-induced aging of the skin. Therefore, the antioxidant and anti-aging effect of Castanea crenata Siebold & Zucc. extracts (LCE) was investigated in this study. The LCE markedly reduced the hydrogen peroxide-induced cell damage, intracellular ROS, and oxidative stress-induced senescence in human dermal fibroblasts (HDFs). These results indicate that LCE might have beneficial effects on oxidative stress-induced damage and thus reduce skin aging.
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KEYWORD
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Reactive oxygen species , Human dermal fibroblast , Antioxidant , Anti-aging
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